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This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.
AAG8; Aging-associated gene 8 protein; AL024364; ALS16; DSMA2; hSigmaR1; mSigmaR1; opioid receptor, sigma 1; Oprs1; RP23 167I12.6; SIG 1R; SIG-1R; sigma 1 receptor variant SR-1D; sigma 1-type opioid receptor; Sigma non-opioid intracellular receptor 1; sigma1 receptor; Sigma-1 Receptor; sigma1R; sigma1-receptor; Sigmar1; SR BP; SR31747 binding protein 1; SR31747-binding protein; SRBP; SR-BP; SR-BP1; zgc:56378
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